I hadn't thought of this before but a big difference between Quine and Sims is that a lot of genetic algorithms have a fitness function.
Matt Hall, Larva Labs on Computation’s Strangeness
What we've done is definitely very much an ode to the old method, where this is very handmade, especially because we have to compress this. The code has to be very small; it has to be very tightly designed so that this whole quine structure works and fits everything.
John Watkinson, Larva Labs on Computation’s Strangeness