The main differences between Botto and Electric Sheep are that Botto uses pretrained neural networks instead of procedural image generation.
Aaron Hertzmann, Aaron Hertzmann on Caring about People
In terms of autonomy, I'd say that Botto is very similar to the Electric Sheep system that Scott Draves made in the 90s. It ran an evolutionary system on its own with user feedback.
Aaron Hertzmann, Aaron Hertzmann on Caring about People